Indiana Avenue is one of the four original diagonal streets in Indianapolis, heading in a northwest-southeast direction. The other three are Virginia Avenue, Kentucky Avenue, and Massachusetts Avenue.
At one point, the entirety of Indiana Avenue was US 52. Indiana Avenue east of West Street was also part of US 421.
Former US 52:
The Indianapolis Urban League headquarters is located along Indiana Avenue. Indiana Avenue was the historical heart of the Black community in Indianapolis.
Indiana Avenue serves as the northern boundary of the IU - Indianapolis / Purdue - Indianapolis (formerly IUPUI) campus.


Former US 52 / US 421:
The Kurt Vonnegut Museum is located along Indiana Avenue.
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